Research Fellow
| Dyddiad hysbysebu: | 02 Chwefror 2026 |
|---|---|
| Cyflog: | £35,608 i £46,049 bob blwyddyn |
| Oriau: | Llawn Amser |
| Dyddiad cau: | 02 Mawrth 2026 |
| Lleoliad: | University of Warwick Campus, Coventry |
| Gweithio o bell: | Hybrid - gweithio o bell hyd at 2 ddiwrnod yr wythnos |
| Cwmni: | University of Warwick |
| Math o swydd: | Dros dro |
| Cyfeirnod swydd: | 110016-0226 |
Crynodeb
Research Fellow Post 110016
Gibbet Hill University of Warwick
Fixed Term |Full Time | 1.0 FTE | 36.5 hours per week
Funding is for 36 months restricted to start by 01.07.2025
Project dates: 01.07.2025 – 30.06.2028
For informal enquiries, please contact Professor Bruno Frenguelli at b.g.frenguelli@warwick.ac.uk
Funder: MRC
Title: UKRI535: Gα-selective adenosine A1 receptor agonists as novel analgesics devoid of cardiorespiratory depression
KEYWORDS: – adenosine, pain, analgesia
We have discovered a novel painkilling mechanism activated by an unusual agonist of the adenosine A1 receptor (A1R).
This agonist, BnOCPA, seems only to activate one of the six Gi/o Gα subunits that adenosine receptors can couple to – the Gob subunit. Since this subunit is found at low levels in the heart, BnOCPA does not affect blood pressure or heart rate, but still acts as a potent analgesic in a preclinical model of neuropathic pain.
In this project, funded by the MRC, we will investigate the cellular and molecular mechanisms of BnOCPA and a related derivative, and test BnOCPA in neuropathic and inflammatory pain models.
About the research group
The project involves three labs at the University of Warwick (Frenguelli, Wall and Zhang). Each group brings specific expertise to the project and different aspects will be overseen as required.
The three groups are part of the Neuroscience Research Cluster in the School of Life Sciences at Warwick University.
We are a diverse group of neuroscientists who study a variety of physiological and pathological process occurring in the nervous system.
Through in silico, molecular, cellular and whole animal approaches, we investigate fundamental properties of synaptic transmission and plasticity, the influence of pathogenic proteins, and the impact and mechanisms of stress, pain and epilepsy.
The labs are located in the Interdisciplinary Biomedical Research Building (IBRB), a new £54m state-of-the-art research facility that combines cutting edge research infrastructure with award-winning architecture.
For more information about our lab visit: https://warwick.ac.uk/fac/sci/lifesci/people/bfrenguelli/
https://warwick.ac.uk/fac/sci/lifesci/people/mwall/
https://warwick.ac.uk/fac/sci/lifesci/people/xzhang/
For details of the BnOCPA paper visit:
https://www.nature.com/articles/s41467-022-31652-2
Any requests for further information about the role can be directed to b.g.frenguelli@warwick.ac.uk
We and the wider University of Warwick environment offer substantial opportunities for professional development including regular opportunities to present research finding at internal, local, national and international conferences.
If you have not yet been awarded your PhD but are near submission or have recently submitted your PhD, any offers of employment will be made as Research Assistant at the top of level 5 within the University grade structure.
Upon successful award of your PhD and evidence of this fact, you will be promoted to Research Fellow on the first point of the level 6 of the University grade structure, unless exceptional experience applies to warrant a higher salary.
The successful applicant will have a PhD or equivalent in neuroscience or a related discipline, and with expertise in experimental studies of physiology, particularly, but not exclusively in electrophysiology (ideally patch-clamping) and/or the behavioural assessment of pain and analgesia.
We also welcome applications from people with a good experimental track record keen to learn new techniques. Applicants should be proficient in experimental research and have a published track record to evidence this.
For details on the experience and skills required, please refer to the job description attached as a PDF below.
PhD Status
If you are near submission of your PhD, or have not yet had it conferred, any offers of employment will be made at Research Assistant level, at the highest spinal point of pay grade 5 (£34,610 per annum).
Upon receipt of evidence confirming the successful award of your PhD, you will be promoted to Research Fellow, at the lowest spinal point of grade 6 (£35,608 per annum).
Gibbet Hill University of Warwick
Fixed Term |Full Time | 1.0 FTE | 36.5 hours per week
Funding is for 36 months restricted to start by 01.07.2025
Project dates: 01.07.2025 – 30.06.2028
For informal enquiries, please contact Professor Bruno Frenguelli at b.g.frenguelli@warwick.ac.uk
Funder: MRC
Title: UKRI535: Gα-selective adenosine A1 receptor agonists as novel analgesics devoid of cardiorespiratory depression
KEYWORDS: – adenosine, pain, analgesia
We have discovered a novel painkilling mechanism activated by an unusual agonist of the adenosine A1 receptor (A1R).
This agonist, BnOCPA, seems only to activate one of the six Gi/o Gα subunits that adenosine receptors can couple to – the Gob subunit. Since this subunit is found at low levels in the heart, BnOCPA does not affect blood pressure or heart rate, but still acts as a potent analgesic in a preclinical model of neuropathic pain.
In this project, funded by the MRC, we will investigate the cellular and molecular mechanisms of BnOCPA and a related derivative, and test BnOCPA in neuropathic and inflammatory pain models.
About the research group
The project involves three labs at the University of Warwick (Frenguelli, Wall and Zhang). Each group brings specific expertise to the project and different aspects will be overseen as required.
The three groups are part of the Neuroscience Research Cluster in the School of Life Sciences at Warwick University.
We are a diverse group of neuroscientists who study a variety of physiological and pathological process occurring in the nervous system.
Through in silico, molecular, cellular and whole animal approaches, we investigate fundamental properties of synaptic transmission and plasticity, the influence of pathogenic proteins, and the impact and mechanisms of stress, pain and epilepsy.
The labs are located in the Interdisciplinary Biomedical Research Building (IBRB), a new £54m state-of-the-art research facility that combines cutting edge research infrastructure with award-winning architecture.
For more information about our lab visit: https://warwick.ac.uk/fac/sci/lifesci/people/bfrenguelli/
https://warwick.ac.uk/fac/sci/lifesci/people/mwall/
https://warwick.ac.uk/fac/sci/lifesci/people/xzhang/
For details of the BnOCPA paper visit:
https://www.nature.com/articles/s41467-022-31652-2
Any requests for further information about the role can be directed to b.g.frenguelli@warwick.ac.uk
We and the wider University of Warwick environment offer substantial opportunities for professional development including regular opportunities to present research finding at internal, local, national and international conferences.
If you have not yet been awarded your PhD but are near submission or have recently submitted your PhD, any offers of employment will be made as Research Assistant at the top of level 5 within the University grade structure.
Upon successful award of your PhD and evidence of this fact, you will be promoted to Research Fellow on the first point of the level 6 of the University grade structure, unless exceptional experience applies to warrant a higher salary.
The successful applicant will have a PhD or equivalent in neuroscience or a related discipline, and with expertise in experimental studies of physiology, particularly, but not exclusively in electrophysiology (ideally patch-clamping) and/or the behavioural assessment of pain and analgesia.
We also welcome applications from people with a good experimental track record keen to learn new techniques. Applicants should be proficient in experimental research and have a published track record to evidence this.
For details on the experience and skills required, please refer to the job description attached as a PDF below.
PhD Status
If you are near submission of your PhD, or have not yet had it conferred, any offers of employment will be made at Research Assistant level, at the highest spinal point of pay grade 5 (£34,610 per annum).
Upon receipt of evidence confirming the successful award of your PhD, you will be promoted to Research Fellow, at the lowest spinal point of grade 6 (£35,608 per annum).