Research Assistant
| Dyddiad hysbysebu: | 23 Ionawr 2026 |
|---|---|
| Cyflog: | £35,311 i £40,528 bob blwyddyn |
| Gwybodaeth ychwanegol am y cyflog: | Including London Weighting |
| Oriau: | Llawn Amser |
| Dyddiad cau: | 11 Chwefror 2026 |
| Lleoliad: | Potters Bar, Hertfordshire |
| Gweithio o bell: | Ar y safle yn unig |
| Cwmni: | The Royal Veterinary College |
| Math o swydd: | Dros dro |
| Cyfeirnod swydd: | PPS-0003-26 |
Crynodeb
We are looking to appoint a highly motivated Research Assistant with a strong interest in infectious disease
research to join Dr Melissa Hart’s group at the Royal Veterinary College (Hawkshead campus). This 4-year,
Wellcome Trust–funded position will contribute to an innovative research programme exploring how
Plasmodium and Babesia parasites invade red blood cells and establish distinct intracellular niches.
About the Project
Plasmodium and Babesia parasites, which cause malaria and malaria-like disease (babesiosis) in humans and
animals must invade and replicate within RBCs to survive – but each pathogen forms and modifies its intracellular
niche very differently. Both enter RBCs via a parasite-generated molecular portal, called the ‘moving junction’, a
process which simultaneously creates a membrane-bound home (the ‘parasitophorous vacuole membrane’, or
PVM) around the invading parasite, separating it from the host cell cytoplasm. However, whilst
Plasmodium parasites remain and grow within their PVMs, Babesia rapidly destroy their PVMs after invasion and
continue their development within the RBC cytoplasm. Using CRISPR Cas9 approaches in combination with realtime
microscopy, we aim to dissect the distinct molecular mechanisms each pathogen employs to form a moving
junction and PVM, and in doing so, understand how these differences lead to PVM stability or destruction.
Understanding how these parasites build and rapidly remodel their intracellular homes will help us identify critical,
targetable weaknesses in their survival strategies to design therapeutic interventions against them.
The Role
The successful candidate will work within a collaborative research team and contribute to the following activities:
In vitro cell culture and synchronization of Plasmodium and Babesia parasites
Generating transgenic Plasmodium and Babesia parasites using CRISPR Cas9 techniques.
Phenotyping transgenic parasites using microscopy and molecular parasitology techniques
General organization and smooth running of the laboratory
About You
We are seeking an enthusiastic, highly organised, and motivated individual who is keen to develop their research
skills in a dynamic laboratory setting.
Essential criteria:
MSc in biological sciences, biomedical sciences, microbiology, parasitology or a closely related subject.
Practical experience with in vitro cell culture (essential) and molecular biology techniques (desired)
Strong organisational skills and attention to detail
Ability to work both independently and as part of a team
Funding
This post is funded for 4 years, starting in March 2026.
Prospective applicants are encouraged to contact Dr Melissa Hart by email: mhart@rvc.ac.uk.
We promote equality of opportunity and diversity within the workplace and welcome applications from all sections
of the community.
We reserve the right to close this vacancy early if we receive sufficient applications for the role.
research to join Dr Melissa Hart’s group at the Royal Veterinary College (Hawkshead campus). This 4-year,
Wellcome Trust–funded position will contribute to an innovative research programme exploring how
Plasmodium and Babesia parasites invade red blood cells and establish distinct intracellular niches.
About the Project
Plasmodium and Babesia parasites, which cause malaria and malaria-like disease (babesiosis) in humans and
animals must invade and replicate within RBCs to survive – but each pathogen forms and modifies its intracellular
niche very differently. Both enter RBCs via a parasite-generated molecular portal, called the ‘moving junction’, a
process which simultaneously creates a membrane-bound home (the ‘parasitophorous vacuole membrane’, or
PVM) around the invading parasite, separating it from the host cell cytoplasm. However, whilst
Plasmodium parasites remain and grow within their PVMs, Babesia rapidly destroy their PVMs after invasion and
continue their development within the RBC cytoplasm. Using CRISPR Cas9 approaches in combination with realtime
microscopy, we aim to dissect the distinct molecular mechanisms each pathogen employs to form a moving
junction and PVM, and in doing so, understand how these differences lead to PVM stability or destruction.
Understanding how these parasites build and rapidly remodel their intracellular homes will help us identify critical,
targetable weaknesses in their survival strategies to design therapeutic interventions against them.
The Role
The successful candidate will work within a collaborative research team and contribute to the following activities:
In vitro cell culture and synchronization of Plasmodium and Babesia parasites
Generating transgenic Plasmodium and Babesia parasites using CRISPR Cas9 techniques.
Phenotyping transgenic parasites using microscopy and molecular parasitology techniques
General organization and smooth running of the laboratory
About You
We are seeking an enthusiastic, highly organised, and motivated individual who is keen to develop their research
skills in a dynamic laboratory setting.
Essential criteria:
MSc in biological sciences, biomedical sciences, microbiology, parasitology or a closely related subject.
Practical experience with in vitro cell culture (essential) and molecular biology techniques (desired)
Strong organisational skills and attention to detail
Ability to work both independently and as part of a team
Funding
This post is funded for 4 years, starting in March 2026.
Prospective applicants are encouraged to contact Dr Melissa Hart by email: mhart@rvc.ac.uk.
We promote equality of opportunity and diversity within the workplace and welcome applications from all sections
of the community.
We reserve the right to close this vacancy early if we receive sufficient applications for the role.
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