Senior/Principal Laboratory Research Scientist: Metabolomics & Lipidomics Specialist
| Dyddiad hysbysebu: | 02 Mai 2025 |
|---|---|
| Cyflog: | £45,700 bob blwyddyn |
| Oriau: | Llawn Amser |
| Dyddiad cau: | 23 Mai 2025 |
| Lleoliad: | NW1 1AW |
| Gweithio o bell: | Ar y safle yn unig |
| Cwmni: | The Francis Crick Institute |
| Math o swydd: | Parhaol |
| Cyfeirnod swydd: | R2159 |
Crynodeb
Job Title: Senior/Principal Laboratory Research Scientist: Metabolomics & Lipidomics Specialist
Details of the role: Permanent, full-time.
Salary: SLRS level from £45,700 per annum plus benefits. PLRS level from £55,555 per annum plus benefits. The role is advertised as a Senior / Principal Laboratory Research Scientist; the appropriate level will be assigned to the successful candidate subject to skills and experience.
Application closing date: 23/05/25 23:59 GMT
About us…
The Francis Crick Institute is Europe’s largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions.
About the role…
This role in the Metabolomics Scientific Technology Platform (STP) will cover both targeted and discovery metabolomics in the context of biological research. The post provides a unique opportunity to work with cutting edge metabolomics techniques and to become deeply involved in the diverse biological research across the Crick.
Key elements of the role will include LC-MS based metabolomics and lipidomics, including independent operation of the state-of-the-art LC-MS instrumentation (most notably Thermo Orbitrap and Agilent triple quadrupole instruments), along with GC-MS studies, too. The role will offer an opportunity to be involved in a broad range of research topics from clinical cohort discovery studies to metabolic pathway activity analysis of in vitro models.
The post holder will drive projects in collaboration with Crick research groups and will be expected to take projects from initial concept and design, through metabolite extraction and sample preparation, and onto data acquisition and analysis.
What you will be doing…
As an S/PLRS at the Crick, you will:
Metabolomics, lipidomics, and mass spectrometry operations (40%). Efficient operation and maintenance of mass spectrometers – particularly liquid chromatography-mass spectrometry (LC-MS), but also gas chromatography-MS (GC-MS).
Data analysis (35%). Effectively use data analysis software to process raw mass spectrometry data and analyse both targeted and large-scale metabolomics datasets, including statistical analysis (i.e. univariate and multivariate analyses)
Training (15%). The post holder will be responsible for training other Crick researchers in the operation of the LC-MS & GC-MS instrumentation.
Laboratory management (10%). The post holder will be responsible for successful day to day operation of the laboratory, with roles including maintenance of safety standards, purchasing, and general organisation, among others.
About you…
The essential criteria you will bring…
Ph.D. or equivalent, in Metabolomics, Biochemistry, Analytical Chemistry, Statistics, Mathematical Modelling, or other relevant, related discipline.
Evidence of significant experience in metabolomics (including lipidomics).
Evidence of significant experience in operation, maintenance, and troubleshooting of hyphenated-mass spectrometry (in particular, LC-MS & GC-MS).
Experience in performance of metabolomics/lipidomics experiments (including experimental design, metabolite extraction, sample preparation, data acquisition, and method development). Stable isotope labelling experience is desirable, but not essential.
Experience in mass spectrometry and metabolomics/lipidomics data analysis and statistics (including targeted and profiling approaches, and concepts such as univariate and multivariate analyses, power calculations, and significance) and use of data analysis software and workflow packages.
Knowledge of experimental design and metabolomics procedures in the context of large cohort studies.
To see the complete job description, click here.
Learn more about Metabolomics here.
About Working at the Crick…
Our values
We are bold. We make space for creative, dynamic and imaginative ideas and approaches.
We are open. We’re highly collaborative and interactive, and make sure our activities are visible to the outside world.
We are collegial. We show respect for one another, work cooperatively and support the wider community.
At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are a Disability Confident: Committed employer. We will make reasonable adjustments if you need them. If you need assistance with applying please email: nicola.gyte@crick.ac.uk
To find out more about life at the Crick click here.
What will you receive?
At the Francis Crick Institute, we value our team members and offer an extensive range of benefits to support their well-being and development:
Visas: Applicants for this role will be eligible for sponsorship to work in the UK.
Generous Leave: 28 days of annual leave, plus three additional days over Christmas and bank holidays.
Pension Scheme: Defined contribution pension with employer contributions of up to 16%.
Health & Well-being:
24/7 GP consultation services.
Occupational health services and mental health support programs.
Eye care vouchers and discounted healthcare plans.
Work-Life Balance:
Back-up care for dependents.
Childcare support allowance.
Annual leave purchase options.
Perks: Discounted gym memberships, bike-to-work scheme, shopping discounts and more.
Development & Recognition: Comprehensive training, mentoring, and a pay structure based on skills and experience.
Details of the role: Permanent, full-time.
Salary: SLRS level from £45,700 per annum plus benefits. PLRS level from £55,555 per annum plus benefits. The role is advertised as a Senior / Principal Laboratory Research Scientist; the appropriate level will be assigned to the successful candidate subject to skills and experience.
Application closing date: 23/05/25 23:59 GMT
About us…
The Francis Crick Institute is Europe’s largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions.
About the role…
This role in the Metabolomics Scientific Technology Platform (STP) will cover both targeted and discovery metabolomics in the context of biological research. The post provides a unique opportunity to work with cutting edge metabolomics techniques and to become deeply involved in the diverse biological research across the Crick.
Key elements of the role will include LC-MS based metabolomics and lipidomics, including independent operation of the state-of-the-art LC-MS instrumentation (most notably Thermo Orbitrap and Agilent triple quadrupole instruments), along with GC-MS studies, too. The role will offer an opportunity to be involved in a broad range of research topics from clinical cohort discovery studies to metabolic pathway activity analysis of in vitro models.
The post holder will drive projects in collaboration with Crick research groups and will be expected to take projects from initial concept and design, through metabolite extraction and sample preparation, and onto data acquisition and analysis.
What you will be doing…
As an S/PLRS at the Crick, you will:
Metabolomics, lipidomics, and mass spectrometry operations (40%). Efficient operation and maintenance of mass spectrometers – particularly liquid chromatography-mass spectrometry (LC-MS), but also gas chromatography-MS (GC-MS).
Data analysis (35%). Effectively use data analysis software to process raw mass spectrometry data and analyse both targeted and large-scale metabolomics datasets, including statistical analysis (i.e. univariate and multivariate analyses)
Training (15%). The post holder will be responsible for training other Crick researchers in the operation of the LC-MS & GC-MS instrumentation.
Laboratory management (10%). The post holder will be responsible for successful day to day operation of the laboratory, with roles including maintenance of safety standards, purchasing, and general organisation, among others.
About you…
The essential criteria you will bring…
Ph.D. or equivalent, in Metabolomics, Biochemistry, Analytical Chemistry, Statistics, Mathematical Modelling, or other relevant, related discipline.
Evidence of significant experience in metabolomics (including lipidomics).
Evidence of significant experience in operation, maintenance, and troubleshooting of hyphenated-mass spectrometry (in particular, LC-MS & GC-MS).
Experience in performance of metabolomics/lipidomics experiments (including experimental design, metabolite extraction, sample preparation, data acquisition, and method development). Stable isotope labelling experience is desirable, but not essential.
Experience in mass spectrometry and metabolomics/lipidomics data analysis and statistics (including targeted and profiling approaches, and concepts such as univariate and multivariate analyses, power calculations, and significance) and use of data analysis software and workflow packages.
Knowledge of experimental design and metabolomics procedures in the context of large cohort studies.
To see the complete job description, click here.
Learn more about Metabolomics here.
About Working at the Crick…
Our values
We are bold. We make space for creative, dynamic and imaginative ideas and approaches.
We are open. We’re highly collaborative and interactive, and make sure our activities are visible to the outside world.
We are collegial. We show respect for one another, work cooperatively and support the wider community.
At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are a Disability Confident: Committed employer. We will make reasonable adjustments if you need them. If you need assistance with applying please email: nicola.gyte@crick.ac.uk
To find out more about life at the Crick click here.
What will you receive?
At the Francis Crick Institute, we value our team members and offer an extensive range of benefits to support their well-being and development:
Visas: Applicants for this role will be eligible for sponsorship to work in the UK.
Generous Leave: 28 days of annual leave, plus three additional days over Christmas and bank holidays.
Pension Scheme: Defined contribution pension with employer contributions of up to 16%.
Health & Well-being:
24/7 GP consultation services.
Occupational health services and mental health support programs.
Eye care vouchers and discounted healthcare plans.
Work-Life Balance:
Back-up care for dependents.
Childcare support allowance.
Annual leave purchase options.
Perks: Discounted gym memberships, bike-to-work scheme, shopping discounts and more.
Development & Recognition: Comprehensive training, mentoring, and a pay structure based on skills and experience.