Antibody Discovery and Engineering Scientist
| Posting date: | 04 March 2025 |
|---|---|
| Hours: | Full time |
| Closing date: | 11 March 2025 |
| Location: | Slough, Berkshire, SL1 3WE |
| Company: | SRG |
| Job type: | Temporary |
| Job reference: | BBBH158411_1741082754 |
Summary
Job Title: Antibody Discovery and Engineering Scientist - Global Biopharmaceutical
Contract: 12-month contract
Location: Slough
Salary: £28.53 PAYE/£38.84 Umbrella
SRG are working with a Global Biopharmaceutical company to help them find a Antibody Discovery and Engineering Scientist to join their busy team.
This is an excellent opportunity to join a dynamic and thriving team of scientists helping to develop and validate new sequence-based and structure-based antibody design approaches. This includes elements of antibody hit identification, sequence optimisation and in silico de novo antibody design. This is a laboratory-based role where a detailed knowledge of molecular biology and microbiological methods, and a proven track record of antibody discovery or protein engineering would be a significant advantage.
Key Responsibilities will include:
- Play a key role in the discovery of therapeutic monoclonal antibodies to support the pipeline and help create value for patients suffering with serious disease.
- Using cutting-edge yeast display for the discovery and optimisation of human antibodies aligned with therapeutic targets.
- Design, construct, and perform selections using bespoke synthetic display libraries to support in silico de novo antibody discovery and optimisation projects.
- The preparation of next generation sequencing (NGS) libraries and their analyses to support antibody discovery and engineering of lead molecules.
- Working closely with computational and CADD scientists, co-develop and apply AI/Deep learning solutions and structure-based approaches to facilitate discovery and engineering of high-quality antibody molecules.
- Contribute to the development and implementation of new methodologies in antibody display and engineering.
- Work flexibly across project teams to ensure delivery of results against expected timelines.
- Present experimental data at cross-functional meetings
Candidate Requirements:
- A PhD (or equivalent) with molecular biology and protein biochemistry knowledge ideally within the antibody space.
- Knowledge and experience in the use of in vitro display libraries for either discovery, affinity maturation, or other protein engineering, preferably to include structure or deep sequence-guided insight would be desirable.
- Demonstrable experience of biochemical techniques for the characterisation of macromolecules such as flow-cytometry, surface plasmon resonance or Bio-layer interferometry would be beneficial.
- Skills in informatic and other computational platforms such as molecular visualisation and next generation sequencing data analysis would be advantageous.
- Highly motivated with excellent attention to detail and critical data analysis skills.
- A trusted ability to deliver to deadlines.
- Excellent communication skills.
Carbon60, Lorien & SRG - The Impellam Group STEM Portfolio are acting as an Employment Business in relation to this vacancy.