Postdoctoral Research Assistant - MRC PPU - UOD1519
| Dyddiad hysbysebu: | 09 May 2024 |
|---|---|
| Cyflog: | £36,024 to £44,263 per year |
| Oriau: | Full time |
| Dyddiad cau: | 08 June 2024 |
| Lleoliad: | Dundee, Dundee, DD1 4HN |
| Cwmni: | University of Dundee |
| Math o swydd: | Temporary |
| Cyfeirnod swydd: | 4202_1715234662 |
Crynodeb
The School of Life Sciences at the University of Dundee is a world-class academic institution with a reputation for the excellence of its research, its high-quality teaching and student experience, and the strong impact of its activities outside academia. With 900 staff from over 60 countries worldwide the School provides a dynamic, multi-national, collegiate and diverse environment with state-of-the-art laboratory, technology and teaching facilities.
We are looking for an exceptional individual to join the Sapkota Lab as a Postdoctoral Research Assistant to characterize the the substrates of the PP2A holoenzyme complex and explore targeted dephosphorylation of specific substrates by redirecting endogenous PP2A holoenzyme complex. The project will utilize CRISPR/Cas9 genome editing to introduce degron tags on the two catalytic subunits of PP2A holoenzyme complex and investigate the substrate landscape upon targeted degradation of the two catalytic subunits simultaneously. We have previously established
>6000 phospho-peptides as potential substrates for PPP2CA subunit (PMID: 38450154). We will also utilize these cells in combination with novel proximity-inducing chimera molecules to redirect PP2A holoenzyme complexes to specific phospho-proteins of interest to explore targeted dephosphorylation.
For details of the Sapkota lab research, please visit https://sites.dundee.ac.uk/sapkota-lab/. For more information, please contact Gopal Sapkota (gsapkota@dundee.ac.uk).
This is a unique opportunity to undertake research in a world-leading and cutting-edge research group within the MRC-PPU. The MRC-PPU is one of the world's most renowned centres for research on protein phosphorylation and ubiquitylation (http://www.ppu.mrc.ac.uk) and has an exciting and collaborative research environment, equipped to the highest international standards. MRC-PPU has a long-standing collaboration with leading pharmaceutical companies. MRC-PPU is located in a beautiful setting overlooking the estuary of the river Tay and embedded within the School of Life Sciences at the University of Dundee.
The position is fixed-term for 6 months.
Who we're looking for:
- PhD with an outstanding track record and at least one first-authored publication in an internationally recognised peer-reviewed journal.
- Strong background in cell and molecular biology, biochemistry, and signal transduction, with expertise in protein chemistry and reversible protein phosphorylation desirable.
- Capable of working in a diverse team, but able to plan and work independently.
- Excellent communication skills and proficiency in English.
Commitment to DORA
The School of Life Sciences has been fully committed to the principals of the San Francisco Declaration on Research Assessment (DORA) since 2013. In assessing applicants, we consider the scientific quality of their published research papers, but do not take into account where the papers were published and do not consider journal-based metrics, such as Journal Impact Factors.
As an internationally diverse institution, we welcome job applicants from all countries and nationalities. The School of Life Sciences is proud to employ staff from over 40 different nations.