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Postdoctoral Research Scientist
| Posting date: | 11 November 2025 |
|---|---|
| Salary: | £39,424 to £47,779 per year, pro rata |
| Hours: | Full time |
| Closing date: | 05 December 2025 |
| Location: | Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, South Parks Road, Oxford, OX1 3QU |
| Remote working: | On-site only |
| Company: | University of Oxford |
| Job type: | Contract |
| Job reference: | 183244 |
Summary
Postdoctoral Research Scientist – Neuronal biologist in restoring lysosomal function in Parkinson’s disease
Department of Physiology, Anatomy & Genetics, Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, South Parks Road, Oxford, OX1 3QU
Contract & job type: Full-time, Fixed-term for 24 months
About us:
At the Department of Physiology Anatomy & Genetics (DPAG) we undertake discovery science where we reassemble physiological processes at the molecular, cellular, tissue and systems level of organisation. In so doing we provide a bridge to translational medicine, and interface between physical and life sciences. We are committed not only to innovative research and the highest standard of teaching, but also to creating an inclusive and supportive working environment.
Overview of the role:
We are seeking a Postdoctoral Research Scientist to join our Laboratory of Molecular Neurodegeneration at the Department of Physiology, Anatomy and Genetics, University of Oxford. The ideal candidate will be a highly motivated and skilled neuroscientist with experience in neurodegenerative disease models, lysosomal biology, and biomarker discovery. Strong expertise in in vivo experimentation and molecular techniques is essential, along with a collaborative mindset and a passion for translational research.
In this role, you will be responsible for investigating the mechanisms of action of novel lysosomal modulators in transgenic mouse models of Parkinson’s disease. You will assess therapeutic efficacy, identify biomarkers of lysosomal activity, and contribute to the development of innovative treatments for Parkinson’s disease. This post is available for 24 months.
Key responsibilities:
• Test the impact of novel small molecule drugs targeted to the lysosomal system on the lysosome function in Parkinson’s transgenic mouse models
• Undertake biomarker analysis in Parkinson’s transgenic mouse models to identify biomarkers of improved lysosome activity
• Perform biochemistry, immunohistochemistry and molecular neuropathology studies in brain samples from transgenic mice
• Undertake genotyping, breeding and maintenance of transgenic mouse lines
• Contribute ideas for new research projects and develop ideas for generating research income
• Manage own academic research and administrative activities involving small scale project management
• Act as a source of information and advice to other members of the group on scientific protocols and experimental techniques
• Collaborate in the preparation of scientific reports and journal articles and present papers and posters
• Test hypotheses and analyse scientific data from a variety of sources, reviewing and refining working hypotheses as appropriate
Selection criteria:
• Hold or be near to completion of PhD or DPhil degree in neuroscience or cell/molecular biology, or equivalent.
• Have knowledge and experience of working with transgenic mouse models of neurological disease or neurodegenerative diseases, such as Parkinson’s
• Have experience in biochemistry and immunohistochemistry analysis in mouse brain tissue
• Hold, or be capable of obtaining, a UK Home Office personal licence with relevant authorities to conduct required procedures. NB: professional training will be provided if you do not already have a personal licence
• Be highly motivated, with the capacity to think creatively and work across teams
• Show commitment to engaging with, and promoting awareness of, equality, diversity and inclusion and embedding these into your work.
•
What we offer:
Your wellbeing at work matters, so we offer a range of family friendly and financial benefits including:
• An excellent contributory pension scheme
• 38 days annual leave
• A comprehensive range of childcare services
• Family leave schemes
• Cycle and electric car loan schemes
• Employee Assistance Programme
• Membership to a variety of social and sports clubs
• Discounted bus travel and Season Ticket travel loans
How to apply:
Please provide a supporting statement outlining how you meet the selection criteria along with your CV, and the details of two referees as part of your online application.
The closing date for applications is 12 noon on Friday 5th December.
Interviews are likely to take place during the week commencing 15th December, and will be either face to face or held on Microsoft Teams.
Applications are particularly welcome from women, black and minority ethnic candidates who are under-represented in academic posts in Oxford.
Follow us:
Stay connected with us on LinkedIn, Bluesky and Instagram to learn more about our work and culture. Informal enquiries about the role may be directed to the DPAG HR Team: hr@dpag.ox.ac.uk
DPAG’s Statement of Inclusion:
We, as a Department and Community, will be considerate and welcoming of all people, regardless of age, disability, gender reassignment, marriage and civil partnership, pregnancy and maternity, race, religion or belief, sex, sexual orientation, gender identity, and socio-economic background. We acknowledge societal inequalities and how these impact us, and those around us, personally and professionally. Our policies, practices and Respectful Behaviours Framework underpin this commitment.
DPAG and Sustainability:
We have signed up to The Laboratory Efficiency Assessment Framework (LEAF) and Green Impact, actively implementing and encouraging eco-friendly practices that reduce waste, promote energy efficiency, and promote bio-diversity. See the job description for more detail.
Department of Physiology, Anatomy & Genetics, Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, South Parks Road, Oxford, OX1 3QU
Contract & job type: Full-time, Fixed-term for 24 months
About us:
At the Department of Physiology Anatomy & Genetics (DPAG) we undertake discovery science where we reassemble physiological processes at the molecular, cellular, tissue and systems level of organisation. In so doing we provide a bridge to translational medicine, and interface between physical and life sciences. We are committed not only to innovative research and the highest standard of teaching, but also to creating an inclusive and supportive working environment.
Overview of the role:
We are seeking a Postdoctoral Research Scientist to join our Laboratory of Molecular Neurodegeneration at the Department of Physiology, Anatomy and Genetics, University of Oxford. The ideal candidate will be a highly motivated and skilled neuroscientist with experience in neurodegenerative disease models, lysosomal biology, and biomarker discovery. Strong expertise in in vivo experimentation and molecular techniques is essential, along with a collaborative mindset and a passion for translational research.
In this role, you will be responsible for investigating the mechanisms of action of novel lysosomal modulators in transgenic mouse models of Parkinson’s disease. You will assess therapeutic efficacy, identify biomarkers of lysosomal activity, and contribute to the development of innovative treatments for Parkinson’s disease. This post is available for 24 months.
Key responsibilities:
• Test the impact of novel small molecule drugs targeted to the lysosomal system on the lysosome function in Parkinson’s transgenic mouse models
• Undertake biomarker analysis in Parkinson’s transgenic mouse models to identify biomarkers of improved lysosome activity
• Perform biochemistry, immunohistochemistry and molecular neuropathology studies in brain samples from transgenic mice
• Undertake genotyping, breeding and maintenance of transgenic mouse lines
• Contribute ideas for new research projects and develop ideas for generating research income
• Manage own academic research and administrative activities involving small scale project management
• Act as a source of information and advice to other members of the group on scientific protocols and experimental techniques
• Collaborate in the preparation of scientific reports and journal articles and present papers and posters
• Test hypotheses and analyse scientific data from a variety of sources, reviewing and refining working hypotheses as appropriate
Selection criteria:
• Hold or be near to completion of PhD or DPhil degree in neuroscience or cell/molecular biology, or equivalent.
• Have knowledge and experience of working with transgenic mouse models of neurological disease or neurodegenerative diseases, such as Parkinson’s
• Have experience in biochemistry and immunohistochemistry analysis in mouse brain tissue
• Hold, or be capable of obtaining, a UK Home Office personal licence with relevant authorities to conduct required procedures. NB: professional training will be provided if you do not already have a personal licence
• Be highly motivated, with the capacity to think creatively and work across teams
• Show commitment to engaging with, and promoting awareness of, equality, diversity and inclusion and embedding these into your work.
•
What we offer:
Your wellbeing at work matters, so we offer a range of family friendly and financial benefits including:
• An excellent contributory pension scheme
• 38 days annual leave
• A comprehensive range of childcare services
• Family leave schemes
• Cycle and electric car loan schemes
• Employee Assistance Programme
• Membership to a variety of social and sports clubs
• Discounted bus travel and Season Ticket travel loans
How to apply:
Please provide a supporting statement outlining how you meet the selection criteria along with your CV, and the details of two referees as part of your online application.
The closing date for applications is 12 noon on Friday 5th December.
Interviews are likely to take place during the week commencing 15th December, and will be either face to face or held on Microsoft Teams.
Applications are particularly welcome from women, black and minority ethnic candidates who are under-represented in academic posts in Oxford.
Follow us:
Stay connected with us on LinkedIn, Bluesky and Instagram to learn more about our work and culture. Informal enquiries about the role may be directed to the DPAG HR Team: hr@dpag.ox.ac.uk
DPAG’s Statement of Inclusion:
We, as a Department and Community, will be considerate and welcoming of all people, regardless of age, disability, gender reassignment, marriage and civil partnership, pregnancy and maternity, race, religion or belief, sex, sexual orientation, gender identity, and socio-economic background. We acknowledge societal inequalities and how these impact us, and those around us, personally and professionally. Our policies, practices and Respectful Behaviours Framework underpin this commitment.
DPAG and Sustainability:
We have signed up to The Laboratory Efficiency Assessment Framework (LEAF) and Green Impact, actively implementing and encouraging eco-friendly practices that reduce waste, promote energy efficiency, and promote bio-diversity. See the job description for more detail.