Postdoctoral Research Scientist – Neuronal cell biologist in Parkinson’s
| Dyddiad hysbysebu: | 02 Rhagfyr 2025 |
|---|---|
| Cyflog: | £39,424 i £47,779 bob blwyddyn, pro rata |
| Oriau: | Llawn Amser |
| Dyddiad cau: | 01 Ionawr 2026 |
| Lleoliad: | Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, South Parks Road, Oxford, OX1 3QU |
| Gweithio o bell: | Ar y safle yn unig |
| Cwmni: | University of Oxford |
| Math o swydd: | Cytundeb |
| Cyfeirnod swydd: | 183711 |
Crynodeb
Contract & job type: Full-time, Fixed-term until 30 September 2027
About us:
At the Department of Physiology Anatomy & Genetics (DPAG) we undertake discovery science where we reassemble physiological processes at the molecular, cellular, tissue and systems level of organisation. In so doing we provide a bridge to translational medicine, and interface between physical and life sciences. We are committed not only to innovative research and the highest standard of teaching, but also to creating an inclusive and supportive working environment.
Overview of the role:
We are seeking a Postdoctoral Research Scientist to join our Laboratory of Molecular Neurodegeneration at the Department of Physiology, Anatomy and Genetics, University of Oxford. The ideal candidate will be a highly motivated and skilled cellular neuroscientist with experience in neurodegenerative disease models, lysosomal and mitochondrial biology. Strong expertise in neuronal differentiation and cellular phenotyping is essential, along with a collaborative mindset and a passion for translational research.
In this role, you will be responsible for differentiating iPSC-derived dopamine neurons and neuronal/glial co-cultures, performing analysis of Parkinson’s molecular and cellular biology and correlate read-outs of cell and molecular biology with detailed clinical phenotypes to contribute to our understanding of Parkinson’s disease. This post is available from January 2026 until 30 September 2027.
Key responsibilities:
• Differentiate iPSC-derived dopamine neurons from Parkinson’s patients and control individuals; develop protocols for neuronal/glial co-cultures
• Perform analysis of Parkinson’s cellular phenotypes using high-content imaging, molecular and cell biology, gene expression and protein biochemistry; undertake assays of mitochondrial and lysosomal function
• Develop methods to correlate read-outs of cell and molecular biology with detailed clinical phenotype of patient subclusters
• Contribute ideas for new research projects and develop ideas for generating research income
• Manage own academic research and administrative activities involving small scale project management
• Act as a source of information and advice to other members of the group on scientific protocols and experimental techniques
• Collaborate in the preparation of scientific reports and journal articles and present papers and posters
• Test hypotheses and analyse scientific data from a variety of sources, reviewing and refining working hypotheses as appropriate
Selection criteria:
• Hold or be near to completion of PhD or DPhil degree in neuroscience or cell/molecular biology, or equivalent.
• Knowledge of the cell and molecular biology mechanisms of Parkinson’s disease, or related neurodegenerative condition
• Experience in neuronal cell culture, preferably in human pluripotent stem cells
• Experience in setting up cellular assays, and techniques in cell and molecular neuroscience
• Ability to manage own academic research and associated activities
• Previous experience of contributing to publications/presentations
• Ability to contribute ideas for new research projects and research income generation
• Excellent communication skills, including the ability to write for publication, present research proposals and results, and represent the research group at meetings
• Commitment to engaging with, and promoting awareness of, equality, diversity and inclusion and embedding these into your work.
What we offer:
Your wellbeing at work matters, so we offer a range of family friendly and financial benefits including:
• An excellent contributory pension scheme
• 38 days annual leave
• A comprehensive range of childcare services
• Family leave schemes
• Cycle and electric car loan schemes
• Employee Assistance Programme
• Membership to a variety of social and sports clubs
• Discounted bus travel and Season Ticket travel loans
How to apply:
Please provide a supporting statement outlining how you meet the selection criteria along with your CV, and the details of two referees as part of your online application.
The closing date for applications is 12 noon on Friday 2nd January 2026.
Interviews are likely to take place during the week commencing 12th January 2026, and will be either face to face or held on Microsoft Teams.
Applications are particularly welcome from women, black and minority ethnic candidates who are under-represented in academic posts in Oxford.
Follow us:
Stay connected with us on LinkedIn, Bluesky and Instagram to learn more about our work and culture. Informal enquiries about the role may be directed to the DPAG HR Team: hr@dpag.ox.ac.uk
DPAG’s Statement of Inclusion:
We, as a Department and Community, will be considerate and welcoming of all people, regardless of age, disability, gender reassignment, marriage and civil partnership, pregnancy and maternity, race, religion or belief, sex, sexual orientation, gender identity, and socio-economic background. We acknowledge societal inequalities and how these impact us, and those around us, personally and professionally. Our policies, practices and Respectful Behaviours Framework underpin this commitment.
DPAG and Sustainability:
We have signed up to The Laboratory Efficiency Assessment Framework (LEAF) and Green Impact, actively implementing and encouraging eco-friendly practices that reduce waste, promote energy efficiency, and promote bio-diversity. See the job description for more detail.
About us:
At the Department of Physiology Anatomy & Genetics (DPAG) we undertake discovery science where we reassemble physiological processes at the molecular, cellular, tissue and systems level of organisation. In so doing we provide a bridge to translational medicine, and interface between physical and life sciences. We are committed not only to innovative research and the highest standard of teaching, but also to creating an inclusive and supportive working environment.
Overview of the role:
We are seeking a Postdoctoral Research Scientist to join our Laboratory of Molecular Neurodegeneration at the Department of Physiology, Anatomy and Genetics, University of Oxford. The ideal candidate will be a highly motivated and skilled cellular neuroscientist with experience in neurodegenerative disease models, lysosomal and mitochondrial biology. Strong expertise in neuronal differentiation and cellular phenotyping is essential, along with a collaborative mindset and a passion for translational research.
In this role, you will be responsible for differentiating iPSC-derived dopamine neurons and neuronal/glial co-cultures, performing analysis of Parkinson’s molecular and cellular biology and correlate read-outs of cell and molecular biology with detailed clinical phenotypes to contribute to our understanding of Parkinson’s disease. This post is available from January 2026 until 30 September 2027.
Key responsibilities:
• Differentiate iPSC-derived dopamine neurons from Parkinson’s patients and control individuals; develop protocols for neuronal/glial co-cultures
• Perform analysis of Parkinson’s cellular phenotypes using high-content imaging, molecular and cell biology, gene expression and protein biochemistry; undertake assays of mitochondrial and lysosomal function
• Develop methods to correlate read-outs of cell and molecular biology with detailed clinical phenotype of patient subclusters
• Contribute ideas for new research projects and develop ideas for generating research income
• Manage own academic research and administrative activities involving small scale project management
• Act as a source of information and advice to other members of the group on scientific protocols and experimental techniques
• Collaborate in the preparation of scientific reports and journal articles and present papers and posters
• Test hypotheses and analyse scientific data from a variety of sources, reviewing and refining working hypotheses as appropriate
Selection criteria:
• Hold or be near to completion of PhD or DPhil degree in neuroscience or cell/molecular biology, or equivalent.
• Knowledge of the cell and molecular biology mechanisms of Parkinson’s disease, or related neurodegenerative condition
• Experience in neuronal cell culture, preferably in human pluripotent stem cells
• Experience in setting up cellular assays, and techniques in cell and molecular neuroscience
• Ability to manage own academic research and associated activities
• Previous experience of contributing to publications/presentations
• Ability to contribute ideas for new research projects and research income generation
• Excellent communication skills, including the ability to write for publication, present research proposals and results, and represent the research group at meetings
• Commitment to engaging with, and promoting awareness of, equality, diversity and inclusion and embedding these into your work.
What we offer:
Your wellbeing at work matters, so we offer a range of family friendly and financial benefits including:
• An excellent contributory pension scheme
• 38 days annual leave
• A comprehensive range of childcare services
• Family leave schemes
• Cycle and electric car loan schemes
• Employee Assistance Programme
• Membership to a variety of social and sports clubs
• Discounted bus travel and Season Ticket travel loans
How to apply:
Please provide a supporting statement outlining how you meet the selection criteria along with your CV, and the details of two referees as part of your online application.
The closing date for applications is 12 noon on Friday 2nd January 2026.
Interviews are likely to take place during the week commencing 12th January 2026, and will be either face to face or held on Microsoft Teams.
Applications are particularly welcome from women, black and minority ethnic candidates who are under-represented in academic posts in Oxford.
Follow us:
Stay connected with us on LinkedIn, Bluesky and Instagram to learn more about our work and culture. Informal enquiries about the role may be directed to the DPAG HR Team: hr@dpag.ox.ac.uk
DPAG’s Statement of Inclusion:
We, as a Department and Community, will be considerate and welcoming of all people, regardless of age, disability, gender reassignment, marriage and civil partnership, pregnancy and maternity, race, religion or belief, sex, sexual orientation, gender identity, and socio-economic background. We acknowledge societal inequalities and how these impact us, and those around us, personally and professionally. Our policies, practices and Respectful Behaviours Framework underpin this commitment.
DPAG and Sustainability:
We have signed up to The Laboratory Efficiency Assessment Framework (LEAF) and Green Impact, actively implementing and encouraging eco-friendly practices that reduce waste, promote energy efficiency, and promote bio-diversity. See the job description for more detail.