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CRF Laboratory Technician

Posting date:	15 May 2025
Salary:	£24,625.00 to £25,674.00 per year
Additional salary information:	£24625.00 - £25674.00 a year
Hours:	Full time
Closing date:	29 May 2025
Location:	Manchester, M20 4BX
Company:	NHS Jobs
Job type:	Permanent
Job reference:	C9413-25-0340

Summary

DUTIES AND RESPONSIBILITIES Communication and Professional Responsibilities 1. Maintain high level communication skills, to work with a wide range of staff from the Trust, the Cancer Research UK Manchester Institute and staff from external sponsor companies. 2. To be able to accurately represent the Clinical Research Facility (CRF) Laboratory: a. At open days/ Patient and Public Involvement and Engagement (PPIE) events, b. To potential companies looking to work with the CRF. 3. Quality control of all biological samples that are received into the Clinical Research Facility Laboratory. That all samples contain all necessary information required for sample processing. 4. Notify a senior member of staff or management of all non-compliance issues and critical incidents encountered in the performance of duties. 5. Adhere to all guidelines and legisation set out by regulatory organisations such as the Human Tissue Authority (HTA), Medicine Healthcare Products Regulatory Agency (MHRA). 6. Ensure patient anonymity of all biological samples to adhere to the General Data Protection Regulations (GDPR) 7. Maintain quality control over all samples shipped on dry ice, refrigerated, or ambient both domestically and internationally, by following International Air Transport Association (IATA) regulations. 8. Maintain Good Clinical Practice (GCP) and Good Laboratory Practice (GLP) at all times, in accordance with current legislation. 9. Knowledge of departmental, trust and trial specific Standard Operating Procedures (SOPs). Assistance in the development of departmental SOPs and documentation will also be required. 10. Knowledge of all clinical protocols, provided by external sponsors for clinical trials which require sample handling. 11. To identify deliveries of stock, identify what is required in the Laboratory, and assist in allocation of shelf space for research-specific deliveries. 12. To further assist in the allocation of space, by assisting teams in discarding out-of-date/unused stock, as per local and trust specific waste management polices. 13. To assist the Senior Laboratory Technician in trial set-up, and capacity and capability queries. Sample handling and processing 1. To receive, process, log, store and ship biological samples in accordance with SOPs. 2. Preparation of samples for analysis according to Standard Operating Procedures both Trust and Trial Specific, including but not exclusive to: a. Whole blood, serum, and plasma, b. Isolation of peripheral blood mononuclear cells (PBMCs), and plasmacytoid dendritic cells (PDc) c. Preparation of platelet-rich plasma (PRP), d. Washing and fixing, snap-freezing and embedding tumour biopsies, e. Weighing, and stabilising urines f. Identification of stool samples g. Manual differential slide preparations from whole blood, and bone marrow aspirates. 3. Ensure the quality control for bulk stocks including solvents for decomtamination, hazardous chemicals, reagents, buffers, dry ice and liquid nitrogen. 4. Ensuring compliance with Trust and departmental health and safety procedures when handling hazardous materials and ensuring untrained staff are not exposed to these materials. 5. Ensuring all trial specific laboratory materials supplied by external companies are adaquate, to complete all processes as outlined in the clinical protocol. Equipment Maintenance and Calibration 1. Responsible for ensuring that all equipment is cleaned, decontaminated calibrated and maintained as necessary. Including but not exclusive to: a. Centrifuges/micro centrifuges, b. Class II Biohazard Safety Cabinets c. Vortex, d. Precision pipettes, e. Weighing scales, f. Fridges/Freezers. 2. Ensure that all of the above is documented appropriate for audit purposes. 3. Assist in allocation and management of freezer space. 4. To perform general laboratory duties, such as cleaning area used for sample preparation to ensure the integrity of all samples processed. Documentation 1. Fill out departmental documentation to record trial activity daily for all biological samples that pass through the laboratory. 2. Fill out departmental documentation to record trial activity daily for all shipments that leave the laboratory to external sites. 3. Ensuring that these documents are legible, clear and concise for archiving to the site file upon trial closure. 4. Ensuring quality control for the completion of departmental documentation including but not exclusive to equipment decontamination, temperature recordings and samples logs both electronic and paper. 5. To perform general clerical duties, such as archiving, filing and photocopying. I.T Skills 1. Computer literacy is necessary using microsoft packages such as Outlook, Excel, and Word. 2. Use of internal electronic resources (including Using CWP, R-PEAK, QPulse etc.) to process and track all samples processed in the Clinical Research Facility Laboratory. Training and Education 1. Undergo all mandatory training outlined by the Trust, including any updates necessary. 2. Attend all training agreed during the Personal Development Review, both internally and externally as agreed with line management, to maintain a high level of competency. 3. Participates in the Trusts annual appraisal procedure, maintaining competence levels within the Department and assists in own personal and professional development 4. Undertake all necessary training provided by trial sponsor companies and external scientist to ensure improvement of this service. 5. Take a supervisory role in helping to train new members of staff to use the Clinical Research Facility Laboratory, including students on work experience. 6. Maintain up to date knowledge of necessary legislation and regulations to help prepare for external audits.