Postdoctoral Fellow – In Vivo
| Posting date: | 25 September 2024 |
|---|---|
| Salary: | £43,210 to £43,210 per year |
| Hours: | Full time |
| Closing date: | 13 October 2024 |
| Location: | London, UK |
| Remote working: | On-site only |
| Company: | The Francis Crick Institute |
| Job type: | Contract |
| Job reference: |
Summary
Postdoctoral Fellow – In Vivo
Short summary
The RNA Virus Replication Lab, headed by Dr David LV Bauer, was established in 2020 at the Francis Crick Institute. Our lab seeks to understand how RNA viruses replicate, how the unique properties of their RNA genome contribute to this process, and how immunity develops and in turn influences viral replication and evolution.
The Project
SARS-CoV-2 evolution has been characterised by antigenic “leaps” comprising large numbers of mutations (e.g. Omicron BA.1/2, then BA.2.86/JN.1) and natural recombination events between different strains (e.g. XBB). Monitoring of persistently infected patients and populations via wastewater suggests convergent evolution of immune escape mutations in Spike as well as fundamental viral adaptation to chronic infection.
This project aims to determine the host and viral factors that drive persistent infection, and their link with leaps of viral evolution using in vivo models. It will involve close collaboration with leading UK virology labs, as part of the Genotype-to-Phenotype 2 (G2P2-UK) Consortium. The successful candidate will be given wide latitude to decide on the exact aim(s), or to drive an independent project within these areas. (Please note that there is a separate position being advertised for molecular-focused work as well.)
Key Responsibilities
Postdoctoral Fellows will lead their own research project(s) and may contribute to other collaborative projects. They are expected to contribute to a positive lab culture, share their expertise, and train other colleagues. Postdoctoral Fellows are expected to take advantage of the training and network opportunities at the Crick, and are encouraged to build their own independence and leadership in research through attendance at consortium meetings, national and international scientific conferences, and applications for competitive fellowships, and to take the lead in managing their own research with collaborators and the Crick’s core facilities.
Find out what benefits the Crick has to offer:
For more information on our great pay and benefits package please click here: https://www.crick.ac.uk/careers-and-study/life-at-the-crick/pay-and-benefits
Equality, Diversity & Inclusion:
We welcome applications from all backgrounds. We are committed to providing equal employment opportunities, regardless of ethnicity, nationality, gender, sexual orientation, gender identity, religion, pregnancy, age, disability, or civil partnership, marital or family status. We particularly welcome applications from people who are Minority Ethnic as they are currently underrepresented in the Crick at this level.
Diversity is essential to excellence in scientific endeavour. It increases breadth and perspective, leading to more innovation and creativity. We want the Crick to be a place where everyone feels valued and where diversity is celebrated and seen as part of the foundation for our Institute’s success.
The Crick is committed to creating equality of opportunity and promoting diversity and inclusivity. We all share in the responsibility to actively promote dignity, respect, inclusivity and equal treatment and it is our aim to ensure that these principles are reflected and implemented in all strategies, policies and practices.
Read more on our website: https://www.crick.ac.uk/careers-and-study/life-at-the-crick/equality-diversity-and-inclusion
Short summary
The RNA Virus Replication Lab, headed by Dr David LV Bauer, was established in 2020 at the Francis Crick Institute. Our lab seeks to understand how RNA viruses replicate, how the unique properties of their RNA genome contribute to this process, and how immunity develops and in turn influences viral replication and evolution.
The Project
SARS-CoV-2 evolution has been characterised by antigenic “leaps” comprising large numbers of mutations (e.g. Omicron BA.1/2, then BA.2.86/JN.1) and natural recombination events between different strains (e.g. XBB). Monitoring of persistently infected patients and populations via wastewater suggests convergent evolution of immune escape mutations in Spike as well as fundamental viral adaptation to chronic infection.
This project aims to determine the host and viral factors that drive persistent infection, and their link with leaps of viral evolution using in vivo models. It will involve close collaboration with leading UK virology labs, as part of the Genotype-to-Phenotype 2 (G2P2-UK) Consortium. The successful candidate will be given wide latitude to decide on the exact aim(s), or to drive an independent project within these areas. (Please note that there is a separate position being advertised for molecular-focused work as well.)
Key Responsibilities
Postdoctoral Fellows will lead their own research project(s) and may contribute to other collaborative projects. They are expected to contribute to a positive lab culture, share their expertise, and train other colleagues. Postdoctoral Fellows are expected to take advantage of the training and network opportunities at the Crick, and are encouraged to build their own independence and leadership in research through attendance at consortium meetings, national and international scientific conferences, and applications for competitive fellowships, and to take the lead in managing their own research with collaborators and the Crick’s core facilities.
Find out what benefits the Crick has to offer:
For more information on our great pay and benefits package please click here: https://www.crick.ac.uk/careers-and-study/life-at-the-crick/pay-and-benefits
Equality, Diversity & Inclusion:
We welcome applications from all backgrounds. We are committed to providing equal employment opportunities, regardless of ethnicity, nationality, gender, sexual orientation, gender identity, religion, pregnancy, age, disability, or civil partnership, marital or family status. We particularly welcome applications from people who are Minority Ethnic as they are currently underrepresented in the Crick at this level.
Diversity is essential to excellence in scientific endeavour. It increases breadth and perspective, leading to more innovation and creativity. We want the Crick to be a place where everyone feels valued and where diversity is celebrated and seen as part of the foundation for our Institute’s success.
The Crick is committed to creating equality of opportunity and promoting diversity and inclusivity. We all share in the responsibility to actively promote dignity, respect, inclusivity and equal treatment and it is our aim to ensure that these principles are reflected and implemented in all strategies, policies and practices.
Read more on our website: https://www.crick.ac.uk/careers-and-study/life-at-the-crick/equality-diversity-and-inclusion