Postdoctoral Fellow
| Posting date: | 25 September 2024 |
|---|---|
| Salary: | £43,210 to £43,210 per year |
| Hours: | Full time |
| Closing date: | 25 October 2024 |
| Location: | London, UK |
| Remote working: | On-site only |
| Company: | The Francis Crick Institute |
| Job type: | Contract |
| Job reference: |
Summary
Postdoctoral Fellow
Short summary
Work in the Goehring lab aims to understand how cell polarity is established by molecular networks that transduce symmetry-breaking cues into stable molecular asymmetries. Our work focuses on a conserved polarity network defined by the PAR (PAR-titioning defective) proteins, which underlie polarity in diverse contexts, including defining epithelial architecture and function, driving asymmetric division of stem cells, and specifying cell fate of embryonic blastomeres.
Using the C. elegans embryo as a model, our interdisciplinary team combines genetics, quantitative imaging, in vivo biophysics, and mathematical modelling to link system-level properties of the PAR network to molecular behaviours, thereby providing a multi-scale model for how PAR proteins polarize cells in response to developmental cues and ultimately how polarized patterns are read out by the downstream pathways that define a cell's functional polarity.
Key Responsibilities
We aim to recruit a talented and motivated Postdoctoral Training Fellow to join our group. Postdoctoral Training Fellows are expected to lead their own projects, generate and pursue independent research ideas, mentor junior researchers, and contribute to other projects on a collaborative basis (both in the lab and with external collaborators).
Some examples of current projects include:
• Modeling and manipulating PAR network feedback circuits
• Quantitative exploration of kinase-substrate interactions in polarity networks
• Coupling of mechanical(cytoskeletal) and biochemical networks during cell polarization
• Cell cycle control of cell polarity and fate specification pathways
• Canalization of developmental variability during embryogenesis
• Mechanisms for encoding cellular memory
This position offers substantial freedom regarding research direction. The specific project will be developed together with the successful candidate, taking into consideration their specific interests and experience. We welcome applications from diverse backgrounds who can bring new ideas, tools, and/or perspectives to the group.
Find out what benefits the Crick has to offer:
For more information on our great pay and benefits package please click here: https://www.crick.ac.uk/careers-and-study/life-at-the-crick/pay-and-benefits
Equality, Diversity & Inclusion:
We welcome applications from all backgrounds. We are committed to providing equal employment opportunities, regardless of ethnicity, nationality, gender, sexual orientation, gender identity, religion, pregnancy, age, disability, or civil partnership, marital or family status. We particularly welcome applications from people who are Minority Ethnic as they are currently underrepresented in the Crick at this level.
Diversity is essential to excellence in scientific endeavour. It increases breadth and perspective, leading to more innovation and creativity. We want the Crick to be a place where everyone feels valued and where diversity is celebrated and seen as part of the foundation for our Institute’s success.
The Crick is committed to creating equality of opportunity and promoting diversity and inclusivity. We all share in the responsibility to actively promote dignity, respect, inclusivity and equal treatment and it is our aim to ensure that these principles are reflected and implemented in all strategies, policies and practices.
Read more on our website: https://www.crick.ac.uk/careers-and-study/life-at-the-crick/equality-diversity-and-inclusion
Short summary
Work in the Goehring lab aims to understand how cell polarity is established by molecular networks that transduce symmetry-breaking cues into stable molecular asymmetries. Our work focuses on a conserved polarity network defined by the PAR (PAR-titioning defective) proteins, which underlie polarity in diverse contexts, including defining epithelial architecture and function, driving asymmetric division of stem cells, and specifying cell fate of embryonic blastomeres.
Using the C. elegans embryo as a model, our interdisciplinary team combines genetics, quantitative imaging, in vivo biophysics, and mathematical modelling to link system-level properties of the PAR network to molecular behaviours, thereby providing a multi-scale model for how PAR proteins polarize cells in response to developmental cues and ultimately how polarized patterns are read out by the downstream pathways that define a cell's functional polarity.
Key Responsibilities
We aim to recruit a talented and motivated Postdoctoral Training Fellow to join our group. Postdoctoral Training Fellows are expected to lead their own projects, generate and pursue independent research ideas, mentor junior researchers, and contribute to other projects on a collaborative basis (both in the lab and with external collaborators).
Some examples of current projects include:
• Modeling and manipulating PAR network feedback circuits
• Quantitative exploration of kinase-substrate interactions in polarity networks
• Coupling of mechanical(cytoskeletal) and biochemical networks during cell polarization
• Cell cycle control of cell polarity and fate specification pathways
• Canalization of developmental variability during embryogenesis
• Mechanisms for encoding cellular memory
This position offers substantial freedom regarding research direction. The specific project will be developed together with the successful candidate, taking into consideration their specific interests and experience. We welcome applications from diverse backgrounds who can bring new ideas, tools, and/or perspectives to the group.
Find out what benefits the Crick has to offer:
For more information on our great pay and benefits package please click here: https://www.crick.ac.uk/careers-and-study/life-at-the-crick/pay-and-benefits
Equality, Diversity & Inclusion:
We welcome applications from all backgrounds. We are committed to providing equal employment opportunities, regardless of ethnicity, nationality, gender, sexual orientation, gender identity, religion, pregnancy, age, disability, or civil partnership, marital or family status. We particularly welcome applications from people who are Minority Ethnic as they are currently underrepresented in the Crick at this level.
Diversity is essential to excellence in scientific endeavour. It increases breadth and perspective, leading to more innovation and creativity. We want the Crick to be a place where everyone feels valued and where diversity is celebrated and seen as part of the foundation for our Institute’s success.
The Crick is committed to creating equality of opportunity and promoting diversity and inclusivity. We all share in the responsibility to actively promote dignity, respect, inclusivity and equal treatment and it is our aim to ensure that these principles are reflected and implemented in all strategies, policies and practices.
Read more on our website: https://www.crick.ac.uk/careers-and-study/life-at-the-crick/equality-diversity-and-inclusion