Clinical Research Nurse | Guy's and St Thomas' NHS Foundation Trust

Posting date:	27 April 2026
Salary:	Not specified
Additional salary information:	£47,951 - £56,863 p.a. inclusive of HCA
Hours:	Part time
Closing date:	27 May 2026
Location:	London, SE1 9RT
Company:	Guys and St Thomas NHS Foundation Trust
Job type:	Contract
Job reference:	7938771/196-RD471M

Summary

We are seeking an experienced, motivated and proactiveBand 6 Research Nurseto join theAdvancing Repurposed Therapeutics for Epidermolysis Bullosa (ART-EB) clinical trial— an ambitious, innovative Phase 2/3 adaptive multi-arm multi-stage (MAMS) platform study investigating repurposed biologics and biosimilars for adults with Epidermolysis Bullosa (EB).

The successful candidate will be involved in identifying patients suitable for entry into clinical trials by attending clinics, screening medical notes, reviewing consultant referrals, and participating in Multidisciplinary Team (MDT) meetings.

You will contribute to the informed consent process, acting as a point of support for patients and their families, and assist in coordinating the research patient pathway from screening through to trial completion, as required. You will also be responsible for study follow up, data entry, ensuring patient safety and maintaining high levels of quality assurance expected at GSTT.

Applicants must be a registered adult nurse with evidence of continuing professional development. You should have experience of clinical research within the NHS or a strong clinical background with an interest in developing research skills. You will need excellent communication and interpersonal skills, the ability to organise and prioritise your workload, and the confidence to work both independently and as part of a multidisciplinary team while managing a patient caseload across the ART-EB project.

· Coordinate and deliver all aspects of the ART-EB trial and its related research activities

Work autonomously to manage a caseload of patients, providing duty of care and ongoing support to patients and their families throughout participation.

· Work in accordance with the Research Governance Framework, EU Clinical Trials Regulations and ICH Good Clinical Practice (GCP), ensuring protocol compliance at all times.

· Identify eligible patients by attending clinics, screening medical notes, reviewing consultant referrals, and participating in MDT meetings.

· Support the informed consent process by providing clear information and ensuring consent is obtained and documented appropriately.

· Coordinate the research patient pathway from screening through to trial closure, liaising with the trial set-up team and using trial-specific prompts where required.

· Maintain infection prevention and control standards, including minimising cross-infection risk and ensuring safe disposal of body fluids and blood products.

· Support administration of investigational medicinal products (IMPs) as delegated with local nursing teams, and monitor, document and report adverse events/side effects per protocol.

· Maintain accurate, contemporaneous clinical and research records in medical/nursing notes and trial documentation.

Our award-winning dermatology department is known as St John's Institute of Dermatology. It opened in 1863, and is one of the world's leading centres for patients with skin disease. It is the largest dermatology unit in the United Kingdom and has over 60,000 patient episodes per annum, with an unparalleled tertiary referral base.


We treat a range of skin diseases, including rare and very severe conditions that require treatments not available elsewhere in the UK. We are also an internationally recognised centre of skin research focusing on three, interrelated areas with high unmet needs where we have the critical mass of clinical and scientific interdisciplinary excellence - immune-mediated diseases, cancer and rare disease. We aim to better understand fundamental disease mechanisms over time and then identify when and how best to intervene. The internationally leading research programme includes multi-centre observational studies involving longitudinal clinical data and biological sample collections, as well as interventional studies.

Clinical and Patient care
• Ensure the assessment, planning, implementation and evaluation of evidence based, individualised patient/volunteer care.
• Ensure that patients receive high quality clinical care and a good patient experience, having regard for their customs, religious beliefs and doctrines.
• Carry out planned care as required by the clinical trial/study protocol without direct supervision.
• Responsible for setting up and recruiting to, and following up, patients within studies. This includes both randomised clinical trials and other high-quality clinical studies. The role will involve working closely with multidisciplinary clinical teams.
• Act as a patient/volunteer advocate enabling patients to make informed choices concerning their involvement in the clinical trials and ensuring advice and information is provided.
• Ensure there is sufficient skill mix of staff for patient/volunteer safety during clinical trials and ensuring that they are carried out within the Trust and Centre's policies and clinical trial protocols.
• Assist in all clinical aspects of clinical trials including venepuncture, cannulation blood sample processing, drug administration and clinical observation when necessary ensuring that they are carried out within the Trust’s policies, research governance, Medicines for Human Use (Clinical Trials Regulations) Regulations 2004 and Amended Regulations 2006 Incorporating International Conference on Harmonisation of Good Clinical Practice (ICH GCP) Data Protection Act and Human Tissue Act.
• Assist and advise research and clinical staff, both registered and unregistered in the delivery of care to the volunteer.
• Ensure that written informed consent is obtained from every study subject before any study related procedure/s are carried out including sample or data collection, administration of treatment or clinical observation, drug administration and clinical observation. This is in accordance with the Trust research governance arrangements and Medicines for Human Use (Clinical Trials Regulations) Regulations 2004 and Amended Regulations 2006 incorporating International Conference on Harmonisation of Good Clinical Practice (ICH GCP).
• Is wholly accountable for his / her practice in line with the NMC code of professional conduct and takes every reasonable opportunity to sustain and improve his / her knowledge and professional competence related to their specific part of the NMC register.
• Have responsibility for the correct administration and custody of medicines according to Trust policy.
• Record accurately all data obtained throughout a research study and maintain all data and case report forms, both paper and electronic, relating to clinical trials in accordance with the Medicines for Human Use (Clinical Trials Regulations) Regulations 2004 and Amended Regulations 2006 Incorporating International Conference on Harmonisation of Good Clinical Practice (ICH GCP) and the Research Governance Framework.
• Record and report all adverse events observed and reported by study participants in accordance with the protocol, Medicines for Human Use (Clinical Trials Regulations) Regulations 2004 and Amended Regulations 2006 Incorporating International Conference on Harmonisation of Good Clinical Practice (ICH GCP) and the Research Governance Framework.
• Report any deviation from normal practice to senior staff and implement agreed changes in care programme.
• Deal with concerns raised by volunteers and visitors in a proactive manner and take remedial action as necessary.
• To be an effective communicator with patients/carers/families regarding receiving treatment and management as part of a research study.

Quality
• Facilitate a high quality, cost effective specialist service through monitoring and audit and other quality initiatives agreed by the trust.
• Lead on and participate in key developments relating to the speciality so that high quality patient focused care is promoted.
• Provide support to set, monitor and review standards of care on a regular basis and initiate corrective action plans where required.
• Identify and intervene where circumstances contribute to an unsafe environment for patients and staff. To bring such instances to the attention of the senior research nurse or CRF Nurse Manager.

Administration
• Plan, organise and deploy staff according to ability and workload in order to meet patient/volunteer needs.
• Ensure that nursing practices comply with Trust policies and procedures.
• Communicate effectively at all times and maintain a harmonious working environment.
• Maintain a safe environment in accordance with the Health and Safety at Work Act.
• Assist the Nurse Manager in managing incidents, accidents and complaints in accordance with Trust policies and procedures.
• Assist in ensuring the availability of resources for volunteer care.
• Ensure equipment is in good working order, and report appropriately when defective.
• Participate in audits/inspections, e.g. those undertaken by the Medicines and Health Care Regulatory Authority (MHRA), quality control, nursing audits and clinical benchmarking exercises and suggest any change to improve standards.
• Ensure the economical use of resources.
• Contribute to the overall control of the unit or departmental budget and identify areas where cost improvements can be made.
• Ensure the safe custody of patient/volunteers property in accordance with Trust policies.
• Promote and participate in the implementation of policies within the department.
• Promote and participate in the implementation of policies within the department and to ensure compliance with Trust, Government and EU Directives.
• Maintain accurate documentation in clinical trial documents and patient notes.
• Ensure that clinical trial/research study data are effectively archived as required.
• Assist in the process of gaining local regulatory committee approval (ethics and R&D approval).

Education and Training
• Assist in the education and support of health care professionals to enable them to care for clinical trial patients and recruit to clinical trials where appropriate.
• Be responsible for maintaining a Training folder and for keeping all mandatory training and research specific training up to date to support ongoing professional development and compliance with NMC revalidation requirements.
• Maintain an up to date knowledge of research related topics particularly related to clinical trials.
• Attend local and national meetings as appropriate and as agreed with the local co-ordinating centre.
• Attend regular update sessions at GSTT including the Clinical Research Nurse and Midwife Forum.
• Assess the needs of volunteers, relatives and carers and provide them with information as requested.
• Educate and counsel volunteers, family and those who volunteer for clinical trials before, during and after clinical studies and investigations.
• Assist the Senior Research Nurse in orientating all new staff and students to the department.
• Provide teaching and development to the nursing team and students helping them to achieve their learning outcomes.
• Contribute and assist the Senior Research Nurse to foster a learning environment within the clinical area.
• Act as a role model, mentor and preceptor to the nursing team.

Other:
• Understand and adhere to Trust policies and procedures.
• To maintain patient confidentiality and standards of Good Clinical Practice (GCP) at all times.
• Maintain NMC registration and complete 3 yearly NMC revalidation requirements.

Additional Information:
• The post will be required mostly weekdays during core hours and based at Guy’s and St Thomas’ Hospitals. However, it is a requirement of your employment that you be prepared to work at additional locations and have flexibility in relation to working hours/days according to the needs of the projects.


This advert closes on Monday 11 May 2026