Senior Laboratory Research Scientist in Chemical Biology
| Posting date: | 03 December 2024 |
|---|---|
| Salary: | £39,950 to £39,950 per year |
| Hours: | Full time |
| Closing date: | 02 January 2025 |
| Location: | London, UK |
| Remote working: | On-site only |
| Company: | The Francis Crick Institute |
| Job type: | Contract |
| Job reference: |
Summary
Senior Laboratory Research Scientist in Chemical Biology
Short summary
The Molecular Glue (MG) Discovery Partnership represents an exciting research partnership between the Francis Crick Institute and Imperial College working in close collaboration with AstraZeneca. Our aim is to unlock new principles of MG discovery, reveal novel MG biology, and exploit the revolutionary therapeutic potential of molecular glue degraders by developing systematic approaches to exploit endogenous protein degradation pathways to target intractable disease-relevant proteins or protein complexes.
Your role will be to drive discovery and medicinal chemistry optimisation of novel molecular glues, based on starting points discovered through a wide range of biochemical, computational, structural and cellular screening technologies spearheaded by the Partnership. In collaboration with the full team of the Partnership, you will determine the detailed molecular mechanism of action of these glues and unveil new modes of MG degrader activity across diverse targets and effectors (UPS, autophagy).
Both the Partnership and the STP are highly multidisciplinary, encompassing scientists from a variety of backgrounds in an integrated academia-industry setting (chemical biology, cell biology, proteomics, cancer biology, drug discovery, etc.).
Key Responsibilities
• Medicinal chemistry validation and optimisation of hits to generate high quality molecular glue tool compounds (using physicochemical properties, generation and analysis of on-target SAR in biophysical, biochemical and cell-based assays, selectivity profiling, structure-based design etc).
• Collaboration with other STPs and Research Groups within the Partnership to characterise the molecular mechanism of action of small molecule glues, applying biophysical assays, crystallography, cryoEM and omics profiling.
• Design and prosecution of synthetic routes to access small molecule target compounds.
• Continuous professional development as an active member of the scientific community by writing scientific articles, as well as presenting research findings at scientific meetings and/or conferences.
Find out what benefits the Crick has to offer:
For more information on our great pay and benefits package please click here: https://www.crick.ac.uk/careers-and-study/life-at-the-crick/pay-and-benefits
Equality, Diversity & Inclusion:
We welcome applications from all backgrounds. We are committed to providing equal employment opportunities, regardless of ethnicity, nationality, gender, sexual orientation, gender identity, religion, pregnancy, age, disability, or civil partnership, marital or family status. We particularly welcome applications from people who are Minority Ethnic as they are currently underrepresented in the Crick at this level.
Diversity is essential to excellence in scientific endeavour. It increases breadth and perspective, leading to more innovation and creativity. We want the Crick to be a place where everyone feels valued and where diversity is celebrated and seen as part of the foundation for our Institute’s success.
The Crick is committed to creating equality of opportunity and promoting diversity and inclusivity. We all share in the responsibility to actively promote dignity, respect, inclusivity and equal treatment and it is our aim to ensure that these principles are reflected and implemented in all strategies, policies and practices.
Read more on our website: https://www.crick.ac.uk/careers-and-study/life-at-the-crick/equality-diversity-and-inclusion
Short summary
The Molecular Glue (MG) Discovery Partnership represents an exciting research partnership between the Francis Crick Institute and Imperial College working in close collaboration with AstraZeneca. Our aim is to unlock new principles of MG discovery, reveal novel MG biology, and exploit the revolutionary therapeutic potential of molecular glue degraders by developing systematic approaches to exploit endogenous protein degradation pathways to target intractable disease-relevant proteins or protein complexes.
Your role will be to drive discovery and medicinal chemistry optimisation of novel molecular glues, based on starting points discovered through a wide range of biochemical, computational, structural and cellular screening technologies spearheaded by the Partnership. In collaboration with the full team of the Partnership, you will determine the detailed molecular mechanism of action of these glues and unveil new modes of MG degrader activity across diverse targets and effectors (UPS, autophagy).
Both the Partnership and the STP are highly multidisciplinary, encompassing scientists from a variety of backgrounds in an integrated academia-industry setting (chemical biology, cell biology, proteomics, cancer biology, drug discovery, etc.).
Key Responsibilities
• Medicinal chemistry validation and optimisation of hits to generate high quality molecular glue tool compounds (using physicochemical properties, generation and analysis of on-target SAR in biophysical, biochemical and cell-based assays, selectivity profiling, structure-based design etc).
• Collaboration with other STPs and Research Groups within the Partnership to characterise the molecular mechanism of action of small molecule glues, applying biophysical assays, crystallography, cryoEM and omics profiling.
• Design and prosecution of synthetic routes to access small molecule target compounds.
• Continuous professional development as an active member of the scientific community by writing scientific articles, as well as presenting research findings at scientific meetings and/or conferences.
Find out what benefits the Crick has to offer:
For more information on our great pay and benefits package please click here: https://www.crick.ac.uk/careers-and-study/life-at-the-crick/pay-and-benefits
Equality, Diversity & Inclusion:
We welcome applications from all backgrounds. We are committed to providing equal employment opportunities, regardless of ethnicity, nationality, gender, sexual orientation, gender identity, religion, pregnancy, age, disability, or civil partnership, marital or family status. We particularly welcome applications from people who are Minority Ethnic as they are currently underrepresented in the Crick at this level.
Diversity is essential to excellence in scientific endeavour. It increases breadth and perspective, leading to more innovation and creativity. We want the Crick to be a place where everyone feels valued and where diversity is celebrated and seen as part of the foundation for our Institute’s success.
The Crick is committed to creating equality of opportunity and promoting diversity and inclusivity. We all share in the responsibility to actively promote dignity, respect, inclusivity and equal treatment and it is our aim to ensure that these principles are reflected and implemented in all strategies, policies and practices.
Read more on our website: https://www.crick.ac.uk/careers-and-study/life-at-the-crick/equality-diversity-and-inclusion