Warning
This job advert has expired and applications have closed.
Senior Laboratory Research Scientist - High Throughput Screening
| Posting date: | 10 July 2024 |
|---|---|
| Salary: | £39,950 to £42,275 per year |
| Hours: | Full time |
| Closing date: | 28 July 2024 |
| Location: | London, UK |
| Remote working: | Hybrid - work remotely up to 1 day per week |
| Company: | The Francis Crick Institute |
| Job type: | Permanent |
| Job reference: |
Summary
Senior Laboratory Research Scientist - High Throughput Screening
Short summary
The High Throughput Screening (HTS) facility is one of the core science technology platforms (STP’s) available to all researchers at the Crick. We enable researchers at all levels to use large-scale screening techniques as part of their research. Our most popular activities include arrayed genome-wide CRISPR deletion and CRISPRa over-expression screens, genome-wide RNAi screens, large-scale cell-based screens with collections of well-characterised small molecules or proof-of-concept probe or tool discovery screens. The majority of the output of these screens is high content imaging. We also develop novel screening platforms as required by researchers one example of which is our development of a high throughput neutralisation assay to assess the ability of patient serum to prevent SARS Cov-2 infection (now succesfully spun off as a separate unit within the Crick).
Key Responsibilities
• Full project engagement and involvement (both strategically and at the bench) from initial assay development, to prosecuting the screen and final data analysis
• Quickly understand new biological systems and techniques when necessary and drive the whole screening process
• Creation of cell-based assays for high throughput screening applications in collaboration with, and harnessing the expertise of, domain experts
• Using existing High Content Imaging and liquid handling infrastructure effectively and inventively across a wide range of projects
• Employ a range of different reagents and where appropriate reagents are not available, create new ones e.g. creating cell lines
• Independently explore new screening techniques and approaches with a focus on meeting the user’s needs within tight timelines
• Establish viable cell free assays and prosecute such screens at scale with a range of modalities (e.g. HTRF, FP, thermal shift assays)
• Maintaining a productive dialogue with users throughout project lifecycle
Find out what benefits the Crick has to offer:
For more information on our great pay and benefits package please click here: https://www.crick.ac.uk/careers-and-study/life-at-the-crick/pay-and-benefits
Equality, Diversity & Inclusion:
We welcome applications from all backgrounds. We are committed to providing equal employment opportunities, regardless of ethnicity, nationality, gender, sexual orientation, gender identity, religion, pregnancy, age, disability, or civil partnership, marital or family status. We particularly welcome applications from people who are Minority Ethnic as they are currently underrepresented in the Crick at this level.
Diversity is essential to excellence in scientific endeavour. It increases breadth and perspective, leading to more innovation and creativity. We want the Crick to be a place where everyone feels valued and where diversity is celebrated and seen as part of the foundation for our Institute’s success.
The Crick is committed to creating equality of opportunity and promoting diversity and inclusivity. We all share in the responsibility to actively promote dignity, respect, inclusivity and equal treatment and it is our aim to ensure that these principles are reflected and implemented in all strategies, policies and practices.
Read more on our website: https://www.crick.ac.uk/careers-and-study/life-at-the-crick/equality-diversity-and-inclusion
Short summary
The High Throughput Screening (HTS) facility is one of the core science technology platforms (STP’s) available to all researchers at the Crick. We enable researchers at all levels to use large-scale screening techniques as part of their research. Our most popular activities include arrayed genome-wide CRISPR deletion and CRISPRa over-expression screens, genome-wide RNAi screens, large-scale cell-based screens with collections of well-characterised small molecules or proof-of-concept probe or tool discovery screens. The majority of the output of these screens is high content imaging. We also develop novel screening platforms as required by researchers one example of which is our development of a high throughput neutralisation assay to assess the ability of patient serum to prevent SARS Cov-2 infection (now succesfully spun off as a separate unit within the Crick).
Key Responsibilities
• Full project engagement and involvement (both strategically and at the bench) from initial assay development, to prosecuting the screen and final data analysis
• Quickly understand new biological systems and techniques when necessary and drive the whole screening process
• Creation of cell-based assays for high throughput screening applications in collaboration with, and harnessing the expertise of, domain experts
• Using existing High Content Imaging and liquid handling infrastructure effectively and inventively across a wide range of projects
• Employ a range of different reagents and where appropriate reagents are not available, create new ones e.g. creating cell lines
• Independently explore new screening techniques and approaches with a focus on meeting the user’s needs within tight timelines
• Establish viable cell free assays and prosecute such screens at scale with a range of modalities (e.g. HTRF, FP, thermal shift assays)
• Maintaining a productive dialogue with users throughout project lifecycle
Find out what benefits the Crick has to offer:
For more information on our great pay and benefits package please click here: https://www.crick.ac.uk/careers-and-study/life-at-the-crick/pay-and-benefits
Equality, Diversity & Inclusion:
We welcome applications from all backgrounds. We are committed to providing equal employment opportunities, regardless of ethnicity, nationality, gender, sexual orientation, gender identity, religion, pregnancy, age, disability, or civil partnership, marital or family status. We particularly welcome applications from people who are Minority Ethnic as they are currently underrepresented in the Crick at this level.
Diversity is essential to excellence in scientific endeavour. It increases breadth and perspective, leading to more innovation and creativity. We want the Crick to be a place where everyone feels valued and where diversity is celebrated and seen as part of the foundation for our Institute’s success.
The Crick is committed to creating equality of opportunity and promoting diversity and inclusivity. We all share in the responsibility to actively promote dignity, respect, inclusivity and equal treatment and it is our aim to ensure that these principles are reflected and implemented in all strategies, policies and practices.
Read more on our website: https://www.crick.ac.uk/careers-and-study/life-at-the-crick/equality-diversity-and-inclusion