Research Fellow in In-Vivo Protein Folding
| Posting date: | 29 April 2024 |
|---|---|
| Salary: | £34,980 to £42,978 per year |
| Hours: | Full time |
| Closing date: | 27 May 2024 |
| Location: | Southampton, Hampshire |
| Remote working: | On-site only |
| Company: | University of Southampton |
| Job type: | Contract |
| Job reference: | 2703824BJ |
Summary
We are looking for a motivated Post-Doctoral Research Fellow to work with Amrit Mudher and Phil Williamson developing methods to investigate how the cellular milieu influences the folding, structure and function of large molecular complexes including amyloid fibre structure and integral membrane proteins. This Leverhulme Trust funded project will combine the powerful genetic tractability of Drosophila melanogaster with the molecular resolving power of modern sensitive solid-state NMR experiments to report on the structure, dynamics, and function of these assemblies in-vivo.
The project will build on preliminary studies that have demonstrated that modern proton detected ultra-high field solid-state NMR methods can provide the necessary resolution and sensitivity to study the structure and dynamics of large molecular complexes in-situ in the model organism Drosophila melanogaster. The project seeks to establish workflow that will enable the induced expression and labelling of macromolecular complexes and a range of NMR methodologies that permit the characterization of their structure and dynamics as well as interactions with other cellular components.
Ideally applicants should possess a PhD in biochemistry (or related descipline) and ideally experience in either Drosophila research and/or solid-state NMR. The position will be based in the School of Biolgical Sciences, which provides state of the art facilities for invertebrate research and solid-state NMR research (both locally and through the UK National Research Facility). To discuss the position, please don’t hesitate to contact Prof Amrit Mudher (A.Mudher@soton.ac.uk) or Prof Phil Williamson (P.T.Williamson@soton.ac.uk).
*Applications will be considered from candidates who are working towards or nearing completion of a relevant PhD qualification. The title of Research Fellow will be applied upon completion of PhD. Prior to the qualification being awarded the title of Senior Research Assistant will be given.
Working at the University of Southampton:
Check out the staff benefits and why you should join us at The University of Southampton!
As a university we aim to create an environment where everyone can thrive and are proactive in fostering a culture of inclusion, respect and equality of opportunity. We believe that we can only truly meet our objectives if we are reflective of society, so we are passionate about creating a working environment in which you are free to bring your whole self to work. With a generous holiday allowance as well as additional university closure days we are committed to supporting our staff and students and open to a flexible working approach.
This role does not qualify for Skilled Worker Visa sponsorship. To explore alternative UK visas, see gov.uk.
Apply by midnight on the closing date. For assistance contact Recruitment on +44(0)2380 592750 or recruitment@soton.ac.uk quoting the job number.
The project will build on preliminary studies that have demonstrated that modern proton detected ultra-high field solid-state NMR methods can provide the necessary resolution and sensitivity to study the structure and dynamics of large molecular complexes in-situ in the model organism Drosophila melanogaster. The project seeks to establish workflow that will enable the induced expression and labelling of macromolecular complexes and a range of NMR methodologies that permit the characterization of their structure and dynamics as well as interactions with other cellular components.
Ideally applicants should possess a PhD in biochemistry (or related descipline) and ideally experience in either Drosophila research and/or solid-state NMR. The position will be based in the School of Biolgical Sciences, which provides state of the art facilities for invertebrate research and solid-state NMR research (both locally and through the UK National Research Facility). To discuss the position, please don’t hesitate to contact Prof Amrit Mudher (A.Mudher@soton.ac.uk) or Prof Phil Williamson (P.T.Williamson@soton.ac.uk).
*Applications will be considered from candidates who are working towards or nearing completion of a relevant PhD qualification. The title of Research Fellow will be applied upon completion of PhD. Prior to the qualification being awarded the title of Senior Research Assistant will be given.
Working at the University of Southampton:
Check out the staff benefits and why you should join us at The University of Southampton!
As a university we aim to create an environment where everyone can thrive and are proactive in fostering a culture of inclusion, respect and equality of opportunity. We believe that we can only truly meet our objectives if we are reflective of society, so we are passionate about creating a working environment in which you are free to bring your whole self to work. With a generous holiday allowance as well as additional university closure days we are committed to supporting our staff and students and open to a flexible working approach.
This role does not qualify for Skilled Worker Visa sponsorship. To explore alternative UK visas, see gov.uk.
Apply by midnight on the closing date. For assistance contact Recruitment on +44(0)2380 592750 or recruitment@soton.ac.uk quoting the job number.
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