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Postdoctoral Fellow - Adrover Lab
| Dyddiad hysbysebu: | 31 Mai 2024 |
|---|---|
| Cyflog: | £43,210 bob blwyddyn |
| Oriau: | Llawn Amser |
| Dyddiad cau: | 30 Mehefin 2024 |
| Lleoliad: | London, UK |
| Gweithio o bell: | Hybrid - gweithio o bell hyd at 1 diwrnod yr wythnos |
| Cwmni: | The Francis Crick Institute |
| Math o swydd: | Cytundeb |
| Cyfeirnod swydd: |
Crynodeb
Postdoctoral Fellow - Adrover Lab
Short summary
Dr. Adrover’s laboratory focuses on how cancer affects whole-body physiology, with a particular emphasis on the cardiovascular, haematopoietic, and immune systems.
Key Responsibilities
The Cancer Macroenvironment Lab is seeking applications for postdoctoral candidates to carry out experimental work aimed at understanding the interplay between cancer as a systemic disease and cardiovascular disease. The research program will study how cancer affects the haematopoietic stem cell compartment to induce changes in myeloid populations that can explain the abnormally elevated cardiovascular disease of cancer patients.
In this project, some of the specific aims include but are not limited to:
• Using murine models of cancer to analyse the hematopoietic stem and progenitor cell compartment in the bone marrow to understand how the tumour induces changes in neutrophil phenotypes and functions.
• Interrogating the role of neutrophils and other innate immune populations in murine models of cardiovascular disease, including models of thrombosis and acute myocardial infarction, to dissect the role of cancer-imposed changes to the immune compartment in cardiovascular disease outcome.
• Using state of the art in vivo intravital imaging techniques to study the intravascular behaviour of neutrophils in tumour-bearing mice.
Postdoctoral Fellows will lead their own projects, contribute to other projects on a collaborative basis (both in the lab and with external collaborators) and may guide PhD students in their research. The ability to work in a team is essential.
Key experience and competencies
• PhD in immunology, cancer biology, biochemistry or cell biology or in the final stages of PhD submission
• Knowledge and experience in immunology or cancer biology
• Technical expertise in mouse work and microscopy, and experience with experimental design
• Track record of writing papers as evidenced by publications or submitted manuscripts in peer-reviewed journals
Find out what benefits the Crick has to offer:
For more information on our great pay and benefits package please click here: https://www.crick.ac.uk/careers-and-study/life-at-the-crick/pay-and-benefits
Equality, Diversity & Inclusion:
We welcome applications from all backgrounds. We are committed to providing equal employment opportunities, regardless of ethnicity, nationality, gender, sexual orientation, gender identity, religion, pregnancy, age, disability, or civil partnership, marital or family status. We particularly welcome applications from people who are Minority Ethnic as they are currently underrepresented in the Crick at this level.
Diversity is essential to excellence in scientific endeavour. It increases breadth and perspective, leading to more innovation and creativity. We want the Crick to be a place where everyone feels valued and where diversity is celebrated and seen as part of the foundation for our Institute’s success.
The Crick is committed to creating equality of opportunity and promoting diversity and inclusivity. We all share in the responsibility to actively promote dignity, respect, inclusivity and equal treatment and it is our aim to ensure that these principles are reflected and implemented in all strategies, policies and practices.
Read more on our website: https://www.crick.ac.uk/careers-and-study/life-at-the-crick/equality-diversity-and-inclusion
Short summary
Dr. Adrover’s laboratory focuses on how cancer affects whole-body physiology, with a particular emphasis on the cardiovascular, haematopoietic, and immune systems.
Key Responsibilities
The Cancer Macroenvironment Lab is seeking applications for postdoctoral candidates to carry out experimental work aimed at understanding the interplay between cancer as a systemic disease and cardiovascular disease. The research program will study how cancer affects the haematopoietic stem cell compartment to induce changes in myeloid populations that can explain the abnormally elevated cardiovascular disease of cancer patients.
In this project, some of the specific aims include but are not limited to:
• Using murine models of cancer to analyse the hematopoietic stem and progenitor cell compartment in the bone marrow to understand how the tumour induces changes in neutrophil phenotypes and functions.
• Interrogating the role of neutrophils and other innate immune populations in murine models of cardiovascular disease, including models of thrombosis and acute myocardial infarction, to dissect the role of cancer-imposed changes to the immune compartment in cardiovascular disease outcome.
• Using state of the art in vivo intravital imaging techniques to study the intravascular behaviour of neutrophils in tumour-bearing mice.
Postdoctoral Fellows will lead their own projects, contribute to other projects on a collaborative basis (both in the lab and with external collaborators) and may guide PhD students in their research. The ability to work in a team is essential.
Key experience and competencies
• PhD in immunology, cancer biology, biochemistry or cell biology or in the final stages of PhD submission
• Knowledge and experience in immunology or cancer biology
• Technical expertise in mouse work and microscopy, and experience with experimental design
• Track record of writing papers as evidenced by publications or submitted manuscripts in peer-reviewed journals
Find out what benefits the Crick has to offer:
For more information on our great pay and benefits package please click here: https://www.crick.ac.uk/careers-and-study/life-at-the-crick/pay-and-benefits
Equality, Diversity & Inclusion:
We welcome applications from all backgrounds. We are committed to providing equal employment opportunities, regardless of ethnicity, nationality, gender, sexual orientation, gender identity, religion, pregnancy, age, disability, or civil partnership, marital or family status. We particularly welcome applications from people who are Minority Ethnic as they are currently underrepresented in the Crick at this level.
Diversity is essential to excellence in scientific endeavour. It increases breadth and perspective, leading to more innovation and creativity. We want the Crick to be a place where everyone feels valued and where diversity is celebrated and seen as part of the foundation for our Institute’s success.
The Crick is committed to creating equality of opportunity and promoting diversity and inclusivity. We all share in the responsibility to actively promote dignity, respect, inclusivity and equal treatment and it is our aim to ensure that these principles are reflected and implemented in all strategies, policies and practices.
Read more on our website: https://www.crick.ac.uk/careers-and-study/life-at-the-crick/equality-diversity-and-inclusion